I've now been on Lyrica for a few weeks. I've had my initial dose of 200mg a day increased to 350mg a day. I've found the initial feeling of euphoria has worn off and I'm now back to my usual anxious state. I also take Efexor, Lamictal, Clonactil and zimovane. I'm beginning to wonder just how much medication it's going to take me to feel better.