yes IMPOTENCE - big time- (hmmm can you have big time impotence?) i have not been on Lyrica for long but defo impotent since starting (at least on 150 BID) dropped to 75 BID things improved- now back to 150 BID - impotent. I'm not sure if it will improve. At the moment the control of anxiety (which is well controlled by pregabalin) outways the loss of potency - my girlfriend has left me so at least i am not under pressure to perform so i was just planning to "sit it out". Side effects hey!! "he giveth and he taketh away" you have to laugh :-)