i take 120mg of duloxetine 60mg morn and night,, well at docs the other day and he asked if i was depressed i said i dunno,, dont feel it, so we decided to cut the night time one, its been a week and all is ok,, ive been on anti d"s for 14 years you name it ive been on it, so it be instresting to see if any change for the better will happen,, as always i will keep this post going for a little while to update you all .