Wow, okay, that's a large dose of Ven! Saying that, I'm very petite so anything over 150 MG, I can't handle well.
Seroquel really really helps me relax and sleep. It's a good combination that works for me during the night and also day even though it doesn't do much when I'm experiencing panic attacks. Only Klonopin can make me calmer in those situations.
My doctor has told me to only take Seroquel at night, even though I have tried taking it in the mornings, but it makes me too sleepy.
I hope this helps.