my shrink has decided that Lyrica pregabalin was a no go, i got up to 450mg but it seemed to wire me up not calm me down i dropped it to 300mg , the shrink has now added 60mg Cymbalta and i am tapering of pregabalin 200mg fo 2 week and 100mg for 2 week. the Cymbalta has been a cool taper up to yet if not for the double whammy of constipation from both meds . i dread toilet duty its giving me a phobia because of the unknown time of arrival even with a bag full of laxative type meds , Cymbalta a pregabalin togeather are bad for constipation big time