This morning at about 9:15 I took my first 30mg dose of Duloxetine.

I was previously on Mirtazapine, starting back in December, but after going up to 45mg and it not doing the job (it did something, but I fell very far short of remission) it was decided to swap me over to Duloxetine. So for the past 3 weeks I tapered down the Mirtazapine and didn't take any for the past couple of nights.

About an hour or so ago I had quite a large rush of the jitters and a surge of anxiety. I realized why my doctor had given me some Diazepam at this point (not a fan of the idea of benzos, and before a couple weeks ago I'd never taken them, but I've come to accept their usefulness).

Anyhow, I'm here just checking into Cymbalta-world and wondering if anyone can tell me how long I can expect this start-up anxiety to last? (or is that like asking how long a piece of string is...?)

I'm hoping what I've read about start-up anxiety being a good sign of eventual theraputic effect is borne out!

I'll try and post updates about my Duloxetine progress