Re: mirt to duloxatine-does this sound extreme?
Yes I've done several switches from Mirtazapine (before going back) with no problems.
However, I've only been on 15mg so it probably makes a difference.
I went from Mirt to Trazodone with only a 48 hour gap and no taper, and later from Mirt to Citalopram with a days gap too, no taper. I also went straight back on Mirt when they didn't work out.
These switches were under GPs instruction.
I had no apparent adverse effects from these changes.
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Daily Medication for GAD: Mirtazapine 15mg