Originally Posted by
LisaS
She doesn’t agree with Benzodiazapines and would rather I took propranolol in the interim.
I agree with her on the benzodiazepines (BZDs), though probably not for the same reason. The dependency issue is overblown, imho, however, there is strong evidence1 BZDs block the neurogenesis mechanism by which antidepressants work.
Propranolol is a beta-blocker which prevents adrenaline binding to its receptors. This can prevent the adrenaline surge of the flight-or-flight response which can help cope with anxiety, but doesn't directly diminish the anxiety itself. It is definitely worth a try, but if it isn't effective ask for *hydroxyzine instead. It is a mild prescription antihistamine with pretty good anti anxiety properties. Not quite as potent as the BZDs, but often potent enough.
*Hydroxyzine comes in two forms, hydroxyzine pamoate (Vistaril) and hydroxyzine hydrochloride (Atarax). Anecdotally, the pamoate form is claimed to be the more effective anxiolytic, but just how true this is remains a matter of debate in forums.
References:
[1]
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Benzodiazepines and the potential trophic effect of antidepressants on dentate gyrus cells in mood disorders.
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Diazepam treatment blocks the elevation of hippocampal activity and the accelerated proliferation of hippocampal neural stem cells after focal cerebral ischemia in mice.
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A benzodiazepine impairs the neurogenic and behavioural effects of fluoxetine in a rodent model of chronic stress.
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