Can anyone explain to me why the use of Norepinephrine blocking medications can have a positive effect on anxiety disorders. Ie. SNRI’s and TCA’s I can’t understand how these types of medication can lower anxiety levels, in particular imipramine and clomiprimine, along with venlafaxine and other SNRI’s ???

Can someone kindly advise if switching from vorteoxatine to one of the above could be beneficial please. I really need to understand the rationale. So if it comes to it I can make an informed decision all thoughts would be greatly welcomed Thank You