Quote Originally Posted by welshdory View Post
Hi I spoke to my doctor today and he wants to try switching me to duloxetine. Any experience with this one?
I tried it back in the early 1990s. It didn't work for me, but then neither did SSRIs. At least it didn't make my manic as they did.

I rate the TCAs as better and they are often easier to quit, but I understand why he would prefer duloxetine. The NHS advises him that he can switch you from escitalopram to duloxetine overnight whereas it recommends a 2-4 week cross-taper from escitalopram to amitriptyline or imipramine, so a little more complicated to manage and it may take an extra couple of weeks for the new med to kick-in.