I took Mirtazapine( Remeron) for two years. During that time my weight increased by 28 pounds, my urge to eat was insatiable and I became suicidal. My moods were not lightened in any way and I suffered weird trembling of my muscles in bed at night. I looked on the internet and found lots of conversations like this from people saying they'd gained loads of weight and were still feeling depressed or even suicidal. I decided independently of my doctor that this medication was doing me no good. I told him I was feeling fine and dandy now and believed I could come off it. He allowed me to reduce the dose over 3 months and finally stop. I replaced it with excercise and meditation. I've lost all the weight and I'm not depressed. I feel much happier than before I was prescribed it and I'm very grateful that I read reports from ordinary people on sites like this.I cope with the small everyday things that get me down much better than I did when I was taking it. It made me feel much worse and made me so irritable that I was getting angry at any tiny little thing and being terribly offensive to my friends and family. I was also very fat and suicidal!