Hi, I've been on mitrazpine for about 7 weeks now, upped to 45mg a week ago on Monday. I really don't feel it is doing much for my anxiety, I feel so tired and more down if anything now ( even simple tasks seem like hard work where as at the start I was exercising daily). I'm just so drained... I know I may need to be patient but these anxiety/ panic is def increasing and I really feel this med has pooped out. Anyway have any advice? Many thanks x