My doctor wanted me try prozac again, now the 3rd time, and had no success with it helping any with my anxiety. The difference this time is I am on metoprolol and I noticed a good amount of lowering of my resting heart rate and blood pressure. I know prozac is a strong inhibitor of the allele that metabolizes the metoprolol. I have been off the prozac now for 27 days and my resting HR and BP have not returned to my normal levels. Has anyone had this combo of meds and when did you see your rates go back to what they were before the prozac?