Hi again Sandy. The pregabalin would cause the sexual problem that you describe. I discovered this last year as I was seriously considering pregabalin as my anxiety was very bad. I think that I would have accepted the inorgasm. With duloxetine I hoped that the problem would get easier but I wasn't on it long enough to find out. A friend of mine who is a doctor said this would be so but I did not believe him! At least there are no such problems with mirtazapine. At the time it was another thing to feel a failure at. I feel differently about it now. EJ.