I'm also on day 2 of Duloxetine 60mg. I've come straight onto this dose from 45mg Mirtazapine. I wasn't given any diazepam to help with the start up and have been feeling very jittery and unable to sleep through the nights. I had to come off Mirt quickly though as after 9 weeks of swelling up it became unbearable with even my eyelids swelling up with fluid retention. I do hope that this SSNRI helps.