Originally Posted by
Benjammin69
currently my side effects from tapering are sedation during the day due to the 7.5 lower dosage and that’s it.
Which is probably a good indicator that you could stop from 7.5mg without major issues. You can always reintroduce it at 3.75mg if it triggers significant withdrawal
just to also say I have other meds that I take which are helping the withdrawal so propranolol, seroquel and hydroxyzine,
Both quetiapine (Seroquel) and hydroxyzine target the *same receptors at similar potencies as mirtazapine which may account for the lack of significant withdrawal symptoms. While it is not an uncommon combination, I don't really understand why doctors keep prescribing them together.
* Receptor binding potency (Ki) is measured by the amount of drug needed to saturate receptors, the lower the Ki the greater the potency.
Mirtazapine: H1: 1.6 Ki, 5-HT2a: 69.0 Ki, D2: 1000 Ki
Hydroxyzine:H1: 2.0 Ki, 5-HT2a: 50.0 Ki, D2: 378.0 Ki
Quetiapine : H1: 6.9 Ki, 5-HT2a: 118. Ki, D2: 500.0 Ki