Originally Posted by
SideFX
I thought if I force my body to accept it it would resolve itself
Unfortunately, that isn't how these things work. If a side-effect continue to persist beyond when the med kicks-in then it will likely continue as long as you're on it though some degree of tolerance may slowly develop.
My concern is that the Neuropathy becomes permanent and won’t fade once I switch to a TCA med...I’ve asked my GP the question and also the bruxism and she will not commit herself or even say there is a good chance (Talk about sitting on the fence)
She was probably right to do so as there is not much data to go on. My gut feeling is that it will resolve as soon as you stop taking vortioxetine, but I can't guarantee it. Nerves are tricky.
When I was put on quetiapine I would get vibrations in my legs and body and feel disoriented upon waking...This has faded, but still plagues me after more than 2 years. Again I have spoke to my Pdoc, who is completely disinterested...I feel I did something to my dopamine receptors for sure...
The receptors themselves, no. Receptors (and transporters) are simple protein molecules which have limited half-lives, minutes to a few days depending on where they are in the brain (or elsewhere in the nervous system) and how often they are activated. My guess is that your current problem relates to the mirtazapine. There's not a lot of difference in the receptors they both target, although mirtazapine is an even weaker binder to dopamine D1 and D2 receptors than quetiapine:
Mirtazapine: H1: 1.6 Ki, 5-HT2a: 69.0 Ki, D1: 4100 Ki, D2: 1000 Ki,
Quetiapine : H1: 6.9 Ki, 5-HT2a: 118. Ki, D1: 712. Ki, D2: 500.0 Ki