They didn't work, or you couldn't tolerate them, Mark?
I struggled to tolerate a lot of them but stayed on them for example, Prozac, effexor, parnate, phenelzine for a good length
of time. They never helped me though so feel stuck and therapy hasn’t done anything either. Prozac I was on for 18 months and the
others for 4 months. It was only diazepam that enabled me to stay on them.
How did you take them and what happened?
i took them at a low dose but the anxiety was too much especially clomipramine and I just felt in a daze most of the time.
it never got any better the longer I stayed on it.
Yes, mirtazapine and doxepin are very sedating antihistamines which mostly ease anxiety through sedation. They are not really antidepressants which work by stimulating the growth of new brain cells in the hippocampal regions of the brain. That said, they can be effective enough for some.
It is probably worth a try, however, doxepin has been phased out in some countries and I note it isn't listed on the NHS Cost Comparison Chart (
PDF, section 4:3, p 27) which may, or may not indicate it won't be available for much longer in the UK either so it would pay to check. Your chemist/pharmacist could know more about this than your GP.