Re: Citalopram and Heart Rate
Esomeprazole will slow the rate at which citalopram (and many other meds) is metabolised so increasing plasma levels a bit. You'll get a little more bang for buck out of 20mg. This needs to be considered when deciding on dose, but isn't a reason to not take one of them. Such interactions are common and is a primary reason medications must to be prescribed by doctors.
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The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.