Re: Second time around...
Originally Posted by
Speranza
I'm going onto Prozac for the second time - never noticed til today the threads mentioning it 'doesn't work' a second/third/whatever time.
There is good evidence that ADs, especially the SSRIs, become progressively less likely to work each time they are stopped and restarted, but the chances of fluoxetine working for a second time remain fairly high. However, the initial side-effects may be more severe and/or different than last time and you might need to take a higher dose to get the same response.
Racking my brains to remember whether I ended up taking it at night or in the morning. I have a feeling I switched to morning as the tiredness took several hours to kick in. Any bright ideas?
SSRIs are more likely to trigger insomnia but some do find them sedating. Taking fluoxetine at a specific time of day to negate sedation may help for a week or two while plasma levels are in flux, however, it has a very long half-life, up to 6 days for the med itself, plus up to 16 days for its active metabolite, norfluoxetine (which does most of the work), so once plasma levels stabilize it shouldn't matter when you take it.
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The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.