Re: Worse before better on paroxetine?
Originally Posted by
jonjon
I told her about the dizziness and difficulty peeing on 10mg of amitriptyline and she said that should occur when taking much higher doses so this reinforced her belief that I am a slow metabolizer of anti depressant medication.
Amitriptyline is a fairly potent muscarinic acetylcholine antagonist which produces the peeing difficulty, John. But unless your liver, and to a lesser extend kidneys, are completely shot I doubt you're such a slow metaboliser that you can't tolerate less than one seventh of the normal amitriptyline starting dose. There are readily available blood tests to determine TCA plasma levels which would settle the matter.
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The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.