Re: Prozac - What dosage and week finally made a difference?
Originally Posted by
Aundremyles
I'm on 40mg of Prozac on week 3 for extreme anxiety, depression, and stress because I let it go unmanaged for so long. Like crying every day, fear of dying, multiple panic attacks, etc.
You were started on 40mg/day, or have been on 20mg for a while and the dose has been increased because the anxiety and depression worsened?
I'm just wondering when I should feel a difference, lately it's felt like it's made my anxiety worse, but I have hope.
It typically takes 4-12 weeks for an AD to kick-in with fluoxetine likely to become effective at the longer end of the range because of its very long half-life (it takes about 30 days for plasma levels to stabilise). Most ADs will initially make anxiety (also depression) worse because of the greater serotonin activity. Bio-feedback mechanisms usually reduce serotonin synthesis and expression after a few weeks and the heightened anxiety then diminishes, but may return for a while after dose increases.
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The opinions expressed above are based on my observations and, where applicable, interpretation of cited data and are general in nature. Consult your physician before acting on anything stated.