Quote Originally Posted by SideFX View Post
always thought clomiprimine was the stronger serotonin inhibitor of the 2. I have looked at the ki values of both and they seem very similar.
Ki values can vary from lab to lab. Some have paroxetine as the more potent SRI, others clomipramine, but the difference is so small as to make no practicable difference.

Also my mum was on imipramine for decades and it suited her great.
That would be my choice. I was on it for about 5 years at very high doses with minimal side-effects.

Guess if things don't work out with upping the pregabalin I will have to go through withdrawals from vortioxatine and try a TCA.
Switching from vortioxetine to imipramine can be done via a cross-taper which should minimise any withdrawal and/or side-effects. The switch to clomipramine does require a short washout period. See the NHS guideline: Vortioxetine to other antidepressants: switching in adults.

The thought itself is so so scary I can't tell you how afraid I am right now
Why?