Re: Escitalopram to duloxetine
Originally Posted by
smogie
I've had lots of ssri s over the years
Did any of them work well and if so which and why did you stop taking it/them?
but never a snri why ch seems strange?
Switching to a SNRI is indicated if there is no response to SSRIs in the prescribing by the numbers manual. It's usually either that, or mirtazapine and SNRIs are the better of the two options, imo.
There's not much difference between SSRIs and duloxetine in terms of their effect on serotonin, but duloxetine is also a potent inhibitor of noradrenaline, aka norepinephrine, transporters which may make a significant difference, although, as with everything about ADs, there are no guarantees. The dual action ADs are usually less prone to pooping out too.
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