Originally Posted by
panic_down_under
While some begin to experience side-effects within an hour or two of taking a higher dose, a delayed reaction tends to be more common, especially with fluoxetine because of its very long half-life. Unfortunately, the side-effects may also linger for longer for the same reason. It takes about a month for fluoxetine plasma levels to restabilize to a steady-state after a dose increase (or decrease).
I have the opposite, imo worse, pattern, coming out of the blocks in the morning all bright eyed and bushy tailed ready to conquer the world and then fading as the day progresses. Such is life.
Pretty much the same as me, fine in the morning, starts building up mid morning peaking after lunchtime and staying at that level rest of the afternoon and evening. Starts to tail off after 9pm. Had Fluox added to my mirt about 12 months but made no difference so tapered off them, not sure the mirt does anything either but it did give me an appetite for the time in my life! Trying to avoid going down the antipsychotic route but that may be inevitable.