I've been taking pregabalin since 2010 and haven't noticed any adverse change in its effect over the years. Studies are a bit thin on the ground, where six months is often considered "long-term". Also, pregabalin has only been available since 2006 and is licensed for anxiety only in the EU and UK. Nevertheless, there are very many people worldwide taking it long-term for chronic conditions like nerve pain and seizures - if there is anything adverse, it will probably show up there, but I haven't seen anything on Google searches and the like.
If pregabalin is well-tolerated and effective, there doesn't seem to be a strong reason for shifting to another medication once it is settled in. Coordination problems may be a problem for the elderly, but most people report that reduced coordination resolves in the first few weeks of treatment.
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