Originally Posted by
panic_down_under
Given you've needed to take the maximum doses of the two previous antidepressants to achieve a good result increasing the duloxetine dose up to the maximum 120mg would have been better than adding the quetiapine, imho. Some of us, e.g. me, need a lot of antidepressant to get a worthwhile response.
For some reason I can't fathom, it has become the fashion lately to throw an antipsychotic into the med mix at the first hint an antidepressant isn't working even while at low doses. Imho, it should be the very last thing tried.